Division of Chemical and Biological Metrology

home R&D Activities Division of Chemical and Biological Metrology
Research that enriches lives.

The Division of Chemical and Biological Metrology establishes measurement standards and develops certified reference materials for chemical, biological, and ionizing radiation measurements. Based on our world-class measurement capabilities, we provide measurement solutions that meet regulations and industrial needs to improve the quality of life.

Our division develops measurement technologies that are closely related to our daily lives, including food products, the environment, industrial materials, ionizing radiation, diagnostic testing, and the bio-industry. We provide certified reference materials as well as testing and calibration services that are required in the industry through our world-class measurement capabilities, enhancing the reliability of domestic testing institutions and the scientific foundations for government policies.

Director: Dr. Sangil Lee (slee@kriss.re.kr)

Group

  • Gas Metrology (Dr. Jin Sang Jung, jsjung@kriss.re.kr)
  • Inorganic Metrology (Dr. Kyoung Seok Lee, kslee@kriss.re.kr)
  • Biometrology (Dr. Bae Young Kyung, ybae@kriss.re.kr)
  • Ionizing Radiation Metrology (Dr. Kim In Jung, kimij@kriss.re.kr)
  • Organic Metrology (Dr. Ki Hwan Choi, kihwan.choi@kriss.re.kr)
Gas Metrology Group

The Gas Metrology Group establishes and manages measurement standards related to industrial gases (semiconductor, hydrogen, health care, nuclear power etc.), energy gases, toxic gases, forensic gases, greenhouse gases, ambient air/indoor gas pollutants, fine particles, and gas isotope ratios. Additionally, the group develops certified reference materials and provides calibration/testing to disseminate measurement standards to government/research institutions and the industry and provides measurement solutions for domestic and international regulations.

Its current R&D project include the following subjects :

  • • Development of purity analysis methods and certified reference materials for industrial gases (semiconductor, hydrogen, health care, nuclear power etc.), energy gases, greenhouse gases, and ambient air/indoor gas pollutants
  • • Development of measurement standards and certified reference materials for gas isotope ratio
  • • Establishment of fine particle measurement standards and development of measuring instruments
  • • Type approval and accuracy inspections of environmental measuring instruments (atmosphere/smoke stacks)

Toxic Industrial Gas Metrology Team

The Toxic Industrial Gas Metrology Team establishes, manages, and disseminates measurement standards for toxic industrial gases, high-purity gases for semiconductors, air pollutants, and fine dust.

Key Research Fields (Bullet Points)
  • Development of purity analysis technology for toxic industrial gases and semiconductor gases
  • Development of air pollutant and fine particle measurement technology
  • Development of certified reference materials and in-suit measurement technology to support the industry
Gas Isotope Metrology Team

The Gas Isotope Metrology Team establishes, manages, and disseminates measurement standards for the absolute isotope ratios of greenhouse gases/inert gases, gases for industrial processes, and greenhouse gases.

Key Research Fields (Bullet Points)
  • Development of purity analysis methods and certified reference materials for isotope ratios of greenhouse gases/inert gases
  • Development of absolute isotope ratio and atomic weight measurement technology for elements of gas phase molecules
  • Development of radioactive carbon isotope measurement technology based on spectroscopy
Box Close
Inorganic Metrology Group

The Inorganic Metrology Group establishes metrological traceability to the definitions of the SI base units for the amount of substance (unit: mole) and content of inorganic elements and compounds. Additionally, the group establishes and manages measurement standards for food products, the environment, and industrial materials. The group has developed high-level measurement methods and established international equivalence through international comparisons with other national metrology institutes. Through the development and dissemination of various certified reference materials, the Inorganic Metrology Group aims to enhance the reliability of Korea's analysis capabilities in the inorganic analysis field.

Its current R&D project include the following subjects :

  • • Practical realization of the SI base unit mole for elements/ions/inorganic compounds
  • • Development and management of purity analysis methods and the highest grade reference materials for elements/ions/inorganic compounds to ensure metrological traceability to SI base units
  • • Development of certified reference materials for the analysis of harmful elements and nutrient elements in food products
  • • Development of certified reference materials to ensure the reliability of chemical analysis of nuclear power plants
  • • Development of certified reference materials for environmental inorganic analysis of heavy metals in fine dust
  • • Development of certified reference materials for the analysis of key industrial material constituents and doping elements

Inorganic Basic Metrology Team

The Inorganic Basic Metrology Team realizes the SI base unit of amount of substance in chemistry, the mole, by developing key measurement technologies such as electrochemical, isotope ratio measurement, and purity analysis methods for elements/ions/inorganic compounds. Furthermore, the team develops and disseminates certified reference materials such as pure substances, single element standard solutions, and isotope ratio standard solutions for ensuring metrological traceability and establish the core infrastructure of Korea's inorganic analysis capabilities.

Key Research Fields (Bullet Points)
  • Practical realization of the SI base unit mole for elements/ions/inorganic compounds
  • Development and management of purity analysis methods and the highest grade reference materials for elements/ions/inorganic compounds to ensure metrological traceability to SI base units
  • Research on high-level electrochemical measurement methods such as coulometry
  • Development of measurement methods and reference materials for inorganic element isotope ratio
  • Development of measurement technology based on high-energy spectroscopy such as instrumental neutron activation analysis (INAA), and X-ray based chemical species separation analysis methods
Inorganic Reference Material Team

The Inorganic Reference Material Team develops and disseminates measurement standards and certified reference materials through techniques that measures elements/ions/inorganic compounds in a wide array of samples, such as those used in the food industry as well as for environmental, clinical, and industrial material applications. The efforts of the team is aimed at enhancing reliability of measurements in fields that are closely related to the daily lives of the general public. Examples include the development of certified reference materials of food products for harmful/nutrient element analysis and fine dust certified reference materials for harmful element analysis. Furthermore, the team develops certified reference materials related to industrial materials such as plastic and high-purity alumina according to the RoHS Directive, contributing to the competitive growth of national industries.

Key Research Fields (Bullet Points)
  • Research on high-level inorganic element measurement methods such as isotope dilution inductively coupled plasma mass spectroscopy (ID ICP-MS)
  • Development of certified reference materials for the analysis of harmful elements and nutrient elements in food products
  • Development of certified reference materials to ensure the reliability of chemical analysis of nuclear power plants
  • Development of certified reference materials for environmental inorganic analysis of heavy metals in fine dust
  • Development of certified reference materials for the analysis of key industrial material constituents and doping elements
Box Close
Biometrology Group

The Biometrology Group conducts research to establish measurement standards for key biomolecules that make up organisms, such as DNA, proteins, and metabolites. Biometrology includes the development of measurement methods for organisms such as cells, microorganisms, and viruses as well as biological phenomena. In addition, international equivalence is established through international comparative studies with other national metrology institutes. The established biomolecular measurement standards are used to reinforce measurement accuracy and reliability in various fields, including laboratory medicine, pharmaceutical quality control, and food safety, which helps improve the quality of life of all Koreans.

Its current R&D project include the following subjects :

  • • Gene and genome measurement standards: quantitative DNA and RNA analysis, molecular diagnosis, genome reference materials
  • • Protein and proteome measurement standards: quantitative protein analysis, protein reference materials, proteome analysis
  • • Metabolite and metabolome measurement standards: quantitative metabolite analysis reference materials for clinical applications
  • • Cell, microorganism, and virus measurement standards: quantitative cell/microorganism/virus analysis, measurement of cellular responses, reference materials for infectious disease diagnosis

Microbiological Analysis Team

The Microbiological Analysis Team aims to establish an effective public health crisis response platform through the development of microorganism and virus measurement technologies and reference materials for infectious disease diagnosis, treatment, and proficiency testing. Furthermore, the group develops analysis methods for probiotics derived from gastrointestinal microbiota, which are used to help treat metabolic and senile diseases. The standardization research of the Microbiological Analysis Team is targeted towards industry/academia/research/medical demands and contributes to ensuring better public health and food safety.

Key Research Fields (Bullet Points)
  • Development of pathogen analysis technology: measurement technology and reference materials for pathogenic genes, proteins, and metabolites
  • Development of analysis technology for probiotics derived from gastrointestinal microbiota: multi-omics measurement technology and reference materials based on genomes, proteomes, and metabolomes
Biodiagnostics Analysis Team

The Biodiagnostics Metrology Team develops measurement technologies and reference materials in response to emerging needs in the field of biodiagnostics. The team also develops measurement platforms for personalized and preventive health care.

Key Research Fields (Bullet Points)
  • Development of analytical methods and reference materials for laboratory medicine
  • Development of analytical methods for therapeutic drug monitoring
Biomolecular measurement team

Box Close
Ionizing Radiation Metrology Group

The Ionizing Radiation Metrology Group conducts research for the establishment and dissemination of national measurement standards for ionizing radiation. The group develops medical radiation, radiation/radioactivity, and neutron measurement standards and precision measurement standard technology, calibration technology for radiation measuring instruments, and testing and verification technology for radiation equipment. Furthermore, the group offers legal metrology support and radiation equipment calibration/testing services for hospital (clinics), local environmental analysis institutions, research centers/universities that use radiation applications, and nuclear power plants. This is in line with the group's purpose of supporting radiation safety/measurement quality management in the medical, industry, research, and academia fields.

Its current R&D project include the following subjects :

  • • Establishment of monoenergetic neutron measurement standards
  • • Development of absolute absorbed dose to water measurement technology for the medical radiation field
  • • Development of diagnostic radiation dose measurement standards and PET/CT imaging certified reference materials
  • • Establishment of measurement standards for radioactive gases, hard-to-measure radionuclides and radon radioactivity with international equivalence
  • • Development and organization of technology related to radioactivity calibration and proficiency testing for measurement institutions

Neutron Metrology Team

The Neutron Metrology Team actively works to establish and disseminate neutron-related national measurement standards. The team develops monoenergetic neutron measurement standards, thermal neutron measurement standards, as well as isotopic neutron source emission rate measurement technology and neutron energy spectrum measurement technology. Additionally, the team provides calibration and testing service for the neutron field calibration/testing service.

Key Research Fields (Bullet Points)
  • Establishment of monoenergetic neutron measurement standards
  • Establishment of measurement standards for isotopic neutron source emission rate
  • Establishment of thermal neutron measurement standards and development of neutron dosimeter sensitivity calibration technology
  • Development of neutron energy spectrum measurement technology
  • Neutron field calibration/testing services
Dosimetry Metrology Team

The Dosimetry Metrology Team conducts research for the development and dissemination of dosimetry measurement standards for the radiation protection and medical radiation fields. The team develops primary standards based on precision measurement technology for absorbed dose to water and air kerma. Additionally, the team ensures radiation dosage metrological traceability and provides radiation equipment calibration/testing services. Furthermore, the team focuses on R&D regarding imaging standards and certified reference materials for the diagnostic radiation field.

Key Research Fields (Bullet Points)
  • Development of industrial high-dose precision measurement technology and standards
  • Development of absolute absorbed dose to water measurement technology for the medical radiation field
  • Development of diagnostic radiation dose measurement standards and PET/CT imaging certified reference materials
Radioactivity Metrology Team

The Radioactivity Metrology Team is tasked with the development, dissemination, and management of national standards regarding the SI base unit of radioactivity, Bq. The team's research also encompasses the development of radioactivity measurement standards for radioactive gases including radon. Furthermore, the team secures international equivalence, provides calibration/testing services for the radioactivity measurement field, and develops and disseminates various certified reference materials for radioactivity. Through its work, the team aims to contribute to improving radioactivity measurement reliability in Korea and overseas.

Key Research Fields (Bullet Points)
  • Establishment of measurement standards for radioactive gases, hard-to-measure radionuclides, and radon radioactivity measurement standards with international equivalence
  • Development of measurement technology and calibration/testing services for the radioactivity field
  • Development and dissemination of radioactivity certified reference materials
  • Development and organization of technology related to radioactivity calibration and proficiency testing for measurement institutions
Box Close
Organic Metrology Group

The Organic Metrology Group establishes higher-order method and develops certified reference materials regarding organic substances in the fields of food, environment, and product regulations. The group researches purity assessment methods for high-purity organic compounds to develop the certified reference materials that are traceable to the International System of Units. Furthermore, the group actively engages in international comparisons with other national metrology institutes to ensure international equivalence. The group contributes the reliability improvement of testing laboratories by disseminating certified reference materials, supplying samples and reference values for proficiency testing. Additionally, the group is developing measurement technologies for the simultaneous analysis of trace components to cope with new regulations.

Its current R&D project include the following subjects :

  • • Development of purity analysis methods for high-purity organic compounds
  • • Development of higher-order method and certified reference materials regarding regulated substances in food, environment, and industrial products
  • • Development of higher-order method and certified reference materials regarding nutrients in food and active ingredients in pharmaceutical products
  • • Development of higher-order methods for simultaneous multi-component analysis of residual pesticides and residual antibiotics
  • • Development of measurement technology for trace amounts of organic compounds

Organic Metrology Team

The Organic Metrology Team is in the process of developing purity analysis methods for high-purity organic compounds to ensure measurement results of organic compounds are traceable to the International System of Units. Additionally, the team develops measurement technology for trace amounts of organic compounds and uses the developed technology to produce certified reference materials for food safety.

Key Research Fields (Bullet Points)
  • Development of purity analysis methods for high-purity organic compounds
  • Development of measurement technology for trace amounts of organic compounds
  • Development of certified reference materials for food safety
Advanced Organic Analysis Team

The Advanced Organic Analysis Team establishes and maintains measurement standards regarding regulated substances in food, environment, and industrial products in addition to nutrients in food and active ingredients in pharmaceutical products. By developing certified reference materials, the team ensures metrological traceability and presents measurement solutions to relevant industries and institutions.

Key Research Fields (Bullet Points)
  • Development of higher-order method and certified reference materials regarding regulated substances in food, environment, and industrial products
  • Development of higher-order method and certified reference materials regarding nutrients in food and active ingredients in pharmaceutical products
  • Development of higher-order methods for simultaneous multi-component analysis of residual pesticides and residual antibiotics
Box Close