Chemical and Medical Metrology

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The Division Chemical and Medical Metrology researches on measurement technologies for ensuring a happier and richer life. The division serves as the national reference laboratory especially for the fields of environmental protection, health care sectors, food safety, and safety assessment of infrastructures. The division is contributing to a higher quality of life for people by Providing CRMs, and testing and calibration operations to industrial sites, as well as allowing for regulations on measurement capabilities of global levels.

Director: Dr. Sook-Kyung Kim (

Center for

  • Gas Analysis (Dr. Sangil Lee,
  • Bioanalysis (Dr. In Chul Yang,
  • Ionizing Radiation (Dr. Jungho Kim,
  • Analytical Chemistry (Dr. Yong-Hyeon Yim,
  • Medical Convergence Metrology (Dr. Yong-Tae Kim,

Its current R&D project include the following subjects :

  • Establishment and maintenance of national measurement standards for chemical, biological, and ionizing radiation
  • Securing international comparability and equivalence of measurement standards through key comparisons of international standards
  • Harmonization of national measurement results through calibration services and certified reference materials (CRMs)
  • Development and dissemination of CRMs and proficiency test samples
  • New technologies for reliable medical diagnosis and therapy

R&D Highlights _ Chemical and Medical Metrology

Development of primary methods for protein measurement :
no more tricks that would threaten people’s health!

You may remember the “fake milk scandal” in 2008; milk and infant formulas were added with melamine in an illegal attempt to increase their apparent protein content. Such terrifying outcome could have been prevented if more accurate measurements were available for the quantification of protein content. To this end, the Center for Bioanalysis in the Division of Metrology for Quality of Life has carried out project “Development of Protein Measurement Standards” from 2010 to 2014. The research team has developed successfully an accurate and reliable protein measurement system, which includes primary measurement methodologies and certified reference materials (CRM) for a model protein, human growth hormone. The first primary methodology developed by the research team is based on the analysis of amino acids constituting the protein. In addition, through the collaboration with the Center for Inorganic Analysis in the division, the center has developed a novel element-based protein measurement methodology, where protein quantities could be measured based on sulfur content in the proteins. With the successful completion of the project, KRISS now possesses two independent primary methodologies and established its original technology pipeline for the production of protein reference materials. The pipeline includes producing stable isotope-labeled proteins as a gold standard for peptide-based quantification of specific proteins. Building upon successes in establishing protein measurement standards, KRISS will endeavor to develop next-generation measurement methodologies targeting a variety of trace-level proteins in complex matrices.